Studying in vivo bacterial infections at the single cell (bacterial and host) level
Using wild type isogenic tagged strains (WITS) and mathematical/statistical modeling to understand bacterial infection disease dynamics within and between hosts and how antimicrobial therapy and vaccines affect this behavior.
Using transposon mutagenesis and next generation sequencing (TraDIS) to identify novel vaccine candidates which are safe to use in immunocompromised individuals.
Identifying the genetic determinants of bacterial cell shape generation in Campylobacter spp.
To gain an insight into the molecular mechanisms used by Campylobacter jejuni to survive in its host(s) and the environment.
Development of novel therapeutic approaches against Campylobacter spp.