1. Structure-function biology to understand how Toll-like receptors signal. Using a range of different techniques (molecular modeling, imaging techniques (single molecule florescence, FRET) and functional assays) we are investigating on TLRs signal and how signaling may be modified by immunomodulators, adjuvants and allergens. This work involves a number of industry collaborations (GSK, Astra Zeneca).
2. Understanding how the innate immune system impacts on the generation of protective immunity to Salmonella in mice and chickens. Cell biology and in vivo mouse models are used for this work. This is a collaborative project with Zoetis.
3. Understanding how innate immunity impacts of host cell responses to pathogens. We use novel imaging techniques (in collaboration with physical scientists and mathematicians) to determine how PRRs impact on the invasion process and whether this results in physical changes within the cell.