Following undergraduate studies at the University of Plymouth, I moved to the Liverpool School of Tropical Medicine to do a PhD on 'acquired immunity to Onchocerciasis' with Ted Bianco. After 4 years postoc at the University of Bristol studying extrathymic development of gut CD8aa IEL, I moved to (what was then) VLA to work on mouse models of bovine TB in 2001.
Currently I lead a group studying mucosal immunology of TB, the immune response to vaccination and infection to understand: i) How vaccines generate T cell memory and ii) how this affords protective immunity. The overarching strategy: 'understanding how BCG protects allows design of novel TB vaccine strategies'. Using a murine model of M. bovis, we use techniques such as: 11+ colour flow, T cell phenotyping/ sorting, congenic adoptive transfer, to study protective T cells. We are also interested in how vaccine persistance affecs the development of memory.This work uses a One Health approach with many collaborations with human TB research groups.
I am also manager of the APHA Flow Cytometry core facility.