University of Cambridge
I have a long term interest in the immune response to persistent viral infections. Presently we are studying the pathogenesis of gastrointestinal viruses using murine norovirus as a model virus. This can establish both acute and persistent infections. It may also spread from the gut to cause a systemic infection that can lead to pathology in different organ systems. As such it is both a good model system for studying gastrointestinal immunity and mechanisms of viral persistence. We are investigating the role of different cell types and factors in the gut that protect from infection as well as properties of the virus itself that affect its pathogenesis. Previously I have worked with visna maedi virus, a lentiviral infection of sheep. This is a model lentiviral infection with a strict tropism for macrophages and dendritic cells and as such allows the study of viral control mechanisms in the absence of immune deficiencies as is seen with HIV. A common theme of my work is infection of dendritic cells and macrophages and how these infections alter the biology of these important immune cell types. This includes studies with Salmonella enterica as well as the virus infections above.
Biochemistry BSc Hon Aberdeen
Virology PhD Cambridge
Currently Senior Lecturer, Department of Veterinary Medicine, Cambridge