Subunit vaccines designed to control a number of globally important ruminant parasitic infections have recently shown promise. These vaccines mostly comprise cocktails of several proteins. In PARAGONE, the partners are taking the most promising prototypes and testing them in further trials, as well combining some to make multivalent vaccines. For parasites for which vaccines have proved difficult to develop, fundamental studies are being undertaken to inform on the type of host response that needs to be stimulated to obtain protection. These basic studies will feed into selection of appropriate delivery systems. By blending these streams together, the PARAGONE project is taking the current best multicellular parasite vaccine prototypes to the pre-commercialisation stage. The group recently held their Second Consortium Meeting at the University of Ghent in Belgium.
