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Anthony Wilkinson
01904 328261
University of York
Structural Biology, Protein crystallography, Protein biochemistry, Biophysics, Molecular Microbiology
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I have currently funded activity in (i) the area of targeted drug discovery in malaria - in collaboration with medicinal chemists and parasitologists, we are providing the structural insight into the mode of action of inhibitors of the parasite enzyme N-myristoyltransferase and (ii) the virulence determinants of the horse pathogen Rhodococcus equi. Here we have determined structures of members of a family of virulence-associated proteins which enable survival of the pathogen in host macrophages.